COMPUESTOS POTENCIADORES DE LA ACTIVIDAD DE GLICOSIDASAS MUTANTES

Compounds promoting the activity of mutant glycosidases having inhibitory activity for glycosidase enzymes, furthermore relating to a procedure for activation of mutant ß-glycosidase (ß-glucocerebrosidase) and mutant ß-galactosidase in patients suffering lysosomal storage disorders through administr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	GARCIA MORENO, MA. ISABEL, GARCIA FERNANDEZ, JOSE MANUEL, OHNO, KOUSAKU, ORTIZ MELLET, CARMEN, AGUILAR MONCAYO, MATILDE, SUZUKI, YOSHIYUKI
Format:	Patent
Sprache:	spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Compounds promoting the activity of mutant glycosidases having inhibitory activity for glycosidase enzymes, furthermore relating to a procedure for activation of mutant ß-glycosidase (ß-glucocerebrosidase) and mutant ß-galactosidase in patients suffering lysosomal storage disorders through administration of said enzyme competitor inhibitor compounds, characterised by very high bonding specificity and a favourable ratio between the concentration thereof for pharmacological chaperone activity and the concentration thereof for inhibitor activity.