METHOD AND DEVICE FOR THE IN VITRO ANALYSIS OF MRNA OF GENES INVOLVED IN HAEMATOLOGICAL NEOPLASIAS

Method and device for the in vitro analysis of mRNA of genes involved in hematological neoplasias. The device, composed of probes which specifically hybridize with genes involved in hematological neoplasias, designed so that its behaviour in the hybridization is similar, permits the evaluation of th...

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Hauptverfasser:	ALVAREZ CABEZA PATRICIA, SAENZ JIMENEZ PILAR, POCOVI MIERAS MIGUEL, SIMON BUELA LAUREANO, GIRALDO CASTELLANO PILAR, MARTINEZ MARTINEZ ANTONIO
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Method and device for the in vitro analysis of mRNA of genes involved in hematological neoplasias. The device, composed of probes which specifically hybridize with genes involved in hematological neoplasias, designed so that its behaviour in the hybridization is similar, permits the evaluation of the mRNA level in biological samples taken from subjects suspected to be suffering from hematological neoplasia and facilitating the comparison between the different samples and their grouping by similarity in the gene expression patterns, especially when the probes are disposed in the form of microarray. The application of the method of the invention to obtain and process data of gene expression differences from the device of the invention permits the identification of genes significant for distinguishing samples associated to hematological neoplasias, facilitates the diagnosis of neoplasias as CLL and permits making a prognosis of the evolution thereof. Procedimiento y dispositivo de análisis in vitro de mRNA de genes implicados en neoplasias hematológicas. El dispositivo, compuesto de sondas que hibridan de forma específica con genes implicados en neoplasias hematológicas, diseñadas para que su comportamiento en la hibridación sea similar, permite la evaluación del nivel de mRNA en muestras biológicas extraídas de sujetos que se sospecha que pueden padecer una neoplasia hematológica y facilita la comparación entre las distintas muestras y su agrupamiento por similitud en los patrones de expresión de los genes, especialmente cuando las sondas están dispuestas en forma de microarray. La aplicación del método de la invención para obtener y procesar datos de diferencias en expresión génica procedentes del dispositivo de la invención permite la identificación de genes significativos para distinguir muestras asociadas a neoplasias hematológicas, facilita el diagnóstico de neoplasias como la LLC y permite incluso pronosticar la evolución de la misma.