CIS BICYCLIC COMPLEXES OF PLATINUM (II) HAVING ANTICANCER ACTIVITY

The invention relates to compounds having formula (I), wherein: the broken line represents a single or double bond X is N, O, S, or -(CH2)n- n is an integer between 1 and 3 R1 is a radical selected independently from among (C1-C4) alkoxyl, phenoxyl, phenyl-(CH2)r-O R2 and R'2 represent a radical selected independently from among hydrogen, hydroxyl, (C1-C4)-alkoxyl, phenoxyl, phenyl-(CH2)r-O, and O-Gp r is an integer between 1 and 4 Gp is an alcohol protective group, whereby the radicals with benzene rings are optionally mono-, di- or tri-substituted in the benzene rings thereof with (C1-C4)-alkyl, (C1-C4)-alkoxyl and halogen R3 and R'3 represent halogen or, taken together, represent a biradical selected from among -OCO-(CH2)m-COO-, (C3-C7)-cycloalkane-1,1-dicarboxylate, and (C3- C7)-cycloalkane-1,2-dicarboxylate and m is an integer between 0 and 4, which compounds have been shown to be active against different cancer cell lines. Consequently, said compounds are agents that can be used to treat different types of cancer. Complejos bicíclicos cis de platino (II) con actividad anticancerosa. Los compuestos de fórmula (I) donde la línea discontinua representa un enlace simple o doble; X es N, O, S, o -(CH{sub,2}){sub,n}-; n es un entero de 1 a 3; R{sub,1} es un radical independientemente seleccionado entre (C{sub,1}-C{sub,4}) alcoxilo, fenoxilo, fenil (CH{sub,2}){sub,r}-O; R{sub,2} y R''{sub,2} son un radical independientemente seleccionado entre hidrógeno, hidroxilo, (C{sub,1}-C{sub,4})-alcoxilo, fenoxilo, fenil (CH{sub,2}){sub,r}-O, y O-Gp; r es un entero de 1 a 4; Gp es un grupo protector de alcoholes; estando los radicales con anillos bencénicos opcionalmente mono, di- o tri-sustituidos en sus anillos bencénicos por (C{sub,1}-C{sub,4})-alquilo, (C{sub,1}-C{sub,4})-alcoxilo y halógeno; R{sub,3} y R''{sub,3} son halógeno o, tomados conjuntamente, son un birradical seleccionado entre -OCO-(CH{sub,2}){sub,m}-COO-, (C{sub,3}-C{sub,7})-cicloalcano-1,1-dicarboxilato, y (C{sub,3}-C{sub,7}) cicloalcano-1,2-dicarboxilato; y m es un entero de 0 a 4, han mostrado ser activos frente a varias líneas celulares de cáncer. Esto significa que estos compuestos son agentes útiles para tratar varios tipos de cáncer.