DAIRY-PROTEIN-DERIVED PEPTIDES WITH ANGIOTENSIN 1 CONVERTING ENZYME INHIBITORY ACTIVITY

The invention consists in the use of bioactive products derived from dairy proteins - lactoferrin - and the hydrolyzate of lactoferrin that contains said products. This involves a peptide with fifteen amino acid residues (called LfcinB 17-31), and another that is a reduced version thereof (called LfcinB20-25), which are derived from bovine lactoferrin, as effective inhibitors of the angiotensin converting enzyme (ACE). The peptides that are the subject of the patent may be obtained chemically, enzymatically or biotechnologically and give rise to peptides with in vitro and/or ex vivo angiotensin converting enzyme inhibitory activity measured as the reduction in the contraction of rabbit carotid arteries induced by exposure to angiotensin 1. These nutraceutical products, possibly in the form of bioactive peptides, are useful both in the food industry and in the pharmaceutical industry. Uso de péptidos derivados de la lactoferrina para preparar formulaciones inhibidoras de la enzima conversora de angiotensina I. La invención consiste en la utilización de productos bioactivos derivados de las proteínas lácteas. Se trata de un péptido de quince residuos de aminoácidos (llamado LfcinB17 31), y de otro que es una versión reducida del mismo (llamado LfcinB20 25), derivados de la lactoferrina bovina como inhibidores efectivos de la enzima conversora de la angiotensina (ECA). Los péptidos objeto de la patente se pueden obtener químicamente, biotecnológicamente y dan lugar a péptidos con actividad inhibidora de la enzima convertidora de la angiotensina in vitro y/o ex vivo, midiendo la disminución de la contracción de arterias carótidas de conejo inducida por exposición a angiotensina I. Estos productos nutracéuticos, ya sea como péptido biactivos, son tanto útiles para la industria alimentaria como para la farmacéutica.