VECTORES EN LOS QUE SE INSERTA EL GEN C7L Y USO DE LOS MISMOS EN LA FABRICACION DE VACUNAS Y DE COMPOSICIONES PARA TERAPIA GENICA

The recombinant vectors of the invention have an insert with the coding sequence for the C7L gene of vaccinia or of a homologous gene under the control of a promoter that permits its expression. Said vectors protect the cells in which they are expressed from the development of apoptosis. Reinsertion of the C7L gene into the NYVAC genome reverts the apoptotic phenotype of the virus, without losing its attenuation properties. The protection against apoptosis conferred by C7L makes the vectors of the invention suitable for producing live vaccines, by increasing the expression time and presentation of additional antigens encoded in its genome, or for preparing compositions for extended-term gene therapy for actuation in target cells.