RECEPTORES QUIMERICOS Y METODOS PARA IDENTIFICAR COMPUESTOS ACTIVOS EN LOS RECEPTORES DE GLUTAMATO METABOTROPICO Y EL USO DE TALES COMPUESTOS EN EL TRATAMIENTO DE TRASTORNOS Y ENFERMEDADES NEUROLOGICAS

Un receptor quimérico de receptor de glutamato metabotrópico/receptor de calcio acoplado a proteína G (mGluR/ CaR), comprendiendo el receptor quimérico un dominio extracelular, un dominio transmembranal siete, y una cola citoplásmica intracelular, en el que: un dominio o sitio de unión del ligando,...

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Bibliographische Detailangaben
Hauptverfasser:	FULLER, FORREST H, HAMMERLAND, LANCE G, KRAPCHO, KAREN J
Format:	Patent
Sprache:	spa
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Un receptor quimérico de receptor de glutamato metabotrópico/receptor de calcio acoplado a proteína G (mGluR/ CaR), comprendiendo el receptor quimérico un dominio extracelular, un dominio transmembranal siete, y una cola citoplásmica intracelular, en el que: un dominio o sitio de unión del ligando, sitio de acoplamiento de proteína G o sub-dominio 7TMD del CaR se sustituye con el dominio o sub-dominio homólogo del mGluR; o un dominio o sitio de unión del ligando, sitio de acoplamiento de proteína G o sub-dominio 7TMD del mGluR se sustituye con el dominio o subdominio homólogo del CaR; y en el que el receptor quimérico se une a un ligando natural, un agonista o antagonista del mGluR; o un ligando natural, un agonista o antagonista del CaR. The present invention provides chimeric receptors. The chimeric receptors comprise at least one region homologous to a region of a metabotropic glutamate receptor and at least one region homologous to a region of a calcium receptor. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate the activity of metabotropic glutamate receptors or calcium receptors. The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors. Modulation of metabotropic glutamate receptor activity can be used for different purposes such as treating neurological disorders and diseases, inducing an analgesic effect, cognition enhancement, and inducing a muscle-relaxant effect.