PROCEDIMIENTO PARA LA PREPARACION DE FORMILIMIDAZOLES

SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA REACCION CATALITICA DE HIDROXIMETIL - IMIDAZOLES HALOGENADOS PARA OBTENER FORMIL - IMIDAZOLES HALOGENADOS. LA CATALISIS SE REALIZA EN PRESENCIA DE UN PEROXIDO. LOS FORMIL - IMIDAZOLES HALOGENADOS SON PRODUCTOS INTERMEDIOS IMPORTANTES PARA PREPARAR PRINCIPIO...

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Bibliographische Detailangaben
Hauptverfasser:	WELLIG, ALAIN, HEVELING, JOSEF DR
Format:	Patent
Sprache:	spa
Schlagworte:	APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Zusammenfassung:	SE DESCRIBE UN NUEVO PROCEDIMIENTO PARA LA REACCION CATALITICA DE HIDROXIMETIL - IMIDAZOLES HALOGENADOS PARA OBTENER FORMIL - IMIDAZOLES HALOGENADOS. LA CATALISIS SE REALIZA EN PRESENCIA DE UN PEROXIDO. LOS FORMIL - IMIDAZOLES HALOGENADOS SON PRODUCTOS INTERMEDIOS IMPORTANTES PARA PREPARAR PRINCIPIOS ACTIVOS FARMACEUTICOS. Preparation of 4-halo-5-formyl (or 4-formyl-5-halo) - imidazole derivatives (I) comprises catalytically oxidizing the corresponding hydroxymethyl-imidazole compounds (where the formyl is replaced by CH2OH) in the presence of a noble metal catalyst and a peroxide. Preparation of 4-halo-5-formyl (or 4-formyl-5-halo) - imidazole derivatives of formula (I) comprises catalytically oxidizing the corresponding hydroxymethyl-imidazole compounds of formula (III) in the presence of a noble metal catalyst and a peroxide. R1 = H or optionally substituted alkyl; R2 = H or an optionally substituted alkyl, aryl or arylalkyl group; one of R3, R4 = CHO and the other is halo; one of R3, R5 = CH2OH and the other is halo.