FORMA POSOLOGICA DE LIBERACION CONTINUA CON RECUBRIMIENTO DE LATEX Y SU PROCEDIMIENTO DE REALIZACION

Una unidad de forma de dosificación para administrar un agente beneficioso en un fluido, consistiendo la unidad de forma de dosificación en: un núcleo que contiene al menos un agente beneficioso dispersable en un fluido y un agente ligante compatible para unir el agente beneficioso y un revestimiento de látex que envuelve el núcleo, incluyendo el revestimiento de látex una mezcla que contiene un material básico substancialmente hidrofóbico capaz de definir una membrana de tipo matriz y al menos un componente hidrofílico dispersable en el fluido, donde el agente beneficioso es un tinte marcador, o donde el agente beneficioso es un componente saborizante fluorescente. Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.