COMPOSICION DE LIBERACION CONTROLADA QUE COMPRENDE UNA CAPA DE LIBERACION SOSTENIDA Y UNA CAPA DE LIBERACION RAPIDA
Una composición que comprende: (a) una capa de liberación sostenida que comprende (i) un polímero hidrosoluble, y (ii) un primer agente farmacéuticamente activo; y (b) una capa de liberación rápida que comprende (i) un agente formador de matriz, y (ii) un segundo agente farmacéuticamente activo, sie...
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| creator | POSAGE, GARY W WEARLEY, LORRAINE L GOLE, DILIP J WILKINSON, PAUL K LIN, SHUN Y |
| description | Una composición que comprende: (a) una capa de liberación sostenida que comprende (i) un polímero hidrosoluble, y (ii) un primer agente farmacéuticamente activo; y (b) una capa de liberación rápida que comprende (i) un agente formador de matriz, y (ii) un segundo agente farmacéuticamente activo, siendo obtenible dicha composición al verter una primera disolución y una segunda disolución en un recipiente, y liofilizando la disolución resultante, en la que dicha primera disolución comprende dicho polímero hidrosoluble y dicho primer agente farmacéuticamente activo, y dicha segunda disolución comprende dicho agente formador de matriz y dicho segundo agente farmacéuticamente activo.
The present invention provides a composition comprising a sustained release layer and a fast release layer. The sustained release layer comprises a water-soluble polymer and a first pharmaceutically active agent. The fast release layer comprises a matrix forming agent and a second pharmaceutically active agent. Generally, the composition provides fast and sustained (or controlled) release of a pharmaceutically active agent for at least 6 hours and preferably for at least 1 to 3 days. The composition may be incorporated into a dosage unit form, such as a vaginal insert. The compositions are prepared by freeze-drying. |
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The present invention provides a composition comprising a sustained release layer and a fast release layer. The sustained release layer comprises a water-soluble polymer and a first pharmaceutically active agent. The fast release layer comprises a matrix forming agent and a second pharmaceutically active agent. Generally, the composition provides fast and sustained (or controlled) release of a pharmaceutically active agent for at least 6 hours and preferably for at least 1 to 3 days. The composition may be incorporated into a dosage unit form, such as a vaginal insert. The compositions are prepared by freeze-drying.</description><edition>7</edition><language>spa</language><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G ; CHEMISTRY ; COMPOSITIONS BASED THEREON ; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS ; GENERAL PROCESSES OF COMPOUNDING ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; THEIR PREPARATION OR CHEMICAL WORKING-UP ; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS ; WORKING-UP</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050416&DB=EPODOC&CC=ES&NR=2228418T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050416&DB=EPODOC&CC=ES&NR=2228418T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>POSAGE, GARY W</creatorcontrib><creatorcontrib>WEARLEY, LORRAINE L</creatorcontrib><creatorcontrib>GOLE, DILIP J</creatorcontrib><creatorcontrib>WILKINSON, PAUL K</creatorcontrib><creatorcontrib>LIN, SHUN Y</creatorcontrib><title>COMPOSICION DE LIBERACION CONTROLADA QUE COMPRENDE UNA CAPA DE LIBERACION SOSTENIDA Y UNA CAPA DE LIBERACION RAPIDA</title><description>Una composición que comprende: (a) una capa de liberación sostenida que comprende (i) un polímero hidrosoluble, y (ii) un primer agente farmacéuticamente activo; y (b) una capa de liberación rápida que comprende (i) un agente formador de matriz, y (ii) un segundo agente farmacéuticamente activo, siendo obtenible dicha composición al verter una primera disolución y una segunda disolución en un recipiente, y liofilizando la disolución resultante, en la que dicha primera disolución comprende dicho polímero hidrosoluble y dicho primer agente farmacéuticamente activo, y dicha segunda disolución comprende dicho agente formador de matriz y dicho segundo agente farmacéuticamente activo.
The present invention provides a composition comprising a sustained release layer and a fast release layer. The sustained release layer comprises a water-soluble polymer and a first pharmaceutically active agent. The fast release layer comprises a matrix forming agent and a second pharmaceutically active agent. Generally, the composition provides fast and sustained (or controlled) release of a pharmaceutically active agent for at least 6 hours and preferably for at least 1 to 3 days. The composition may be incorporated into a dosage unit form, such as a vaginal insert. The compositions are prepared by freeze-drying.</description><subject>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</subject><subject>GENERAL PROCESSES OF COMPOUNDING</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><subject>USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS</subject><subject>WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZCh29vcN8A_2dPb091NwcVXw8XRyDXIE85z9_UKC_H0cXRwVAkNdFUAKg1z9gGpC_RwVnB0DHNHUB_sHh7j6eQKVR-JSEuQYAJTnYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxrsFGRkYWJoYWISHGxsSoAQAomDhN</recordid><startdate>20050416</startdate><enddate>20050416</enddate><creator>POSAGE, GARY W</creator><creator>WEARLEY, LORRAINE L</creator><creator>GOLE, DILIP J</creator><creator>WILKINSON, PAUL K</creator><creator>LIN, SHUN Y</creator><scope>EVB</scope></search><sort><creationdate>20050416</creationdate><title>COMPOSICION DE LIBERACION CONTROLADA QUE COMPRENDE UNA CAPA DE LIBERACION SOSTENIDA Y UNA CAPA DE LIBERACION RAPIDA</title><author>POSAGE, GARY W ; WEARLEY, LORRAINE L ; GOLE, DILIP J ; WILKINSON, PAUL K ; LIN, SHUN Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2228418TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2005</creationdate><topic>AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>COMPOSITIONS OF MACROMOLECULAR COMPOUNDS</topic><topic>GENERAL PROCESSES OF COMPOUNDING</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><topic>USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS</topic><topic>WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>POSAGE, GARY W</creatorcontrib><creatorcontrib>WEARLEY, LORRAINE L</creatorcontrib><creatorcontrib>GOLE, DILIP J</creatorcontrib><creatorcontrib>WILKINSON, PAUL K</creatorcontrib><creatorcontrib>LIN, SHUN Y</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>POSAGE, GARY W</au><au>WEARLEY, LORRAINE L</au><au>GOLE, DILIP J</au><au>WILKINSON, PAUL K</au><au>LIN, SHUN Y</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSICION DE LIBERACION CONTROLADA QUE COMPRENDE UNA CAPA DE LIBERACION SOSTENIDA Y UNA CAPA DE LIBERACION RAPIDA</title><date>2005-04-16</date><risdate>2005</risdate><abstract>Una composición que comprende: (a) una capa de liberación sostenida que comprende (i) un polímero hidrosoluble, y (ii) un primer agente farmacéuticamente activo; y (b) una capa de liberación rápida que comprende (i) un agente formador de matriz, y (ii) un segundo agente farmacéuticamente activo, siendo obtenible dicha composición al verter una primera disolución y una segunda disolución en un recipiente, y liofilizando la disolución resultante, en la que dicha primera disolución comprende dicho polímero hidrosoluble y dicho primer agente farmacéuticamente activo, y dicha segunda disolución comprende dicho agente formador de matriz y dicho segundo agente farmacéuticamente activo.
The present invention provides a composition comprising a sustained release layer and a fast release layer. The sustained release layer comprises a water-soluble polymer and a first pharmaceutically active agent. The fast release layer comprises a matrix forming agent and a second pharmaceutically active agent. Generally, the composition provides fast and sustained (or controlled) release of a pharmaceutically active agent for at least 6 hours and preferably for at least 1 to 3 days. The composition may be incorporated into a dosage unit form, such as a vaginal insert. The compositions are prepared by freeze-drying.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS GENERAL PROCESSES OF COMPOUNDING HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR PREPARATION OR CHEMICAL WORKING-UP USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS WORKING-UP |
| title | COMPOSICION DE LIBERACION CONTROLADA QUE COMPRENDE UNA CAPA DE LIBERACION SOSTENIDA Y UNA CAPA DE LIBERACION RAPIDA |
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