Set of optically active zopiclone synthesis intermediates comprises carbonates as precursors of zopiclone with enzymatic resolution

Set of optically active zopiclone synthesis intermediates comprises carbonates as precursors of zopiclone with enzymatic resolution

The set of optically-active (+)-zopiclone synthesis intermediates comprises carbonates as precursors of zopiclone. The synthesis also incorporates enzymatic resolution work. In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, wh...

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Bibliographische Detailangaben
Hauptverfasser: DIAZ SIERRA MONICA, BAYOD JASANADA MIGUEL, BRIEVA COLLADO M. ROSARIO, SANCHEZ PEDREGAL VICTOR M, GOTOR SANTAMARIA VICENTE, FERNANDEZ SOLARES LAURA
Format: Patent
Sprache:eng ; spa
Schlagworte:
APPARATUS THEREFOR
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The set of optically-active (+)-zopiclone synthesis intermediates comprises carbonates as precursors of zopiclone. The synthesis also incorporates enzymatic resolution work. In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, where R is chloroalkyl. The present invention also includes several new enzymatic processes for the resolution of the enantiomers of the aforementioned carbonates of formula II from the corresponding racemic mixture. The transformation of these carbonates into zopiclone enantiomerically enriched, constitutes an additional aspect of the invention. Nuevos carbonatos ópticamente activos como intermedios en la síntesis de (+) -zopiclona. Se describen nuevos carbonatos de formula II ópticamente activos precursores de zopiclona, así como procedimientos para su síntesis, resolución enzimática y transformación en (+) - zopiclona.