Mejora del sabor de sustancias activas de medicamentos

LA INTENCION TRATA DE UN PROCEDIMIENTO PARA MEJORAR EL SABOR DE FORMULACIONES SOLIDAS, QUE CONTIENEN UNO O VARIOS PRINCIPIOS ACTIVOS. Improving the taste of solid formulation containing one or more active ingredients comprises co-spray-drying or rotary layer granulation with a polyol or carbohydrate and pressing into final solid form. Pref. a mixture is sprayed in an air stream at 120-300 (pref.140-190) deg C; or swirled in an air stream at 40-120 deg C. Prepn. contains an active ingredient, a polyol, opt. a sweetner and opt. colouring. Sweetner is saccharin, 'Aspartame' (RTM), acesulfame K, neohesperidin DC, sucralose, thaumatin or stevioside. Polyol is sorbitol, mannitol, lactitol, isomaltol, maltitol, erythritol or xylitol. Formulation contains 10-90 (pref. 25-75) wt.% mineral salts of the elements Ca, Mg, Na, K, Fe or Zn, as well as opt. trace elements, opt. vitamins, and opt. bitter tasting substances. Active ingredient comprises 0.1-70 wt.% of the formulation and is an analgesic or antacid.