DERIVADOS DE BENZOCICLOHEXILIMIDAZOLTIONA
LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA DE **FORMULA**, DONDE N ES 0, 1 O 2; T ES O, 1, 2 O 3; R1 ES, INDEPENDIENTEMENTE, HALO, HIDROXI, O CSUB,1-4ALQUILOXI; Y R2 ESTA UNIDO EN POSICION AL, BE O GA, Y ES UN GRUPO SELECCIONADO ENTRE LAS FORMULAS (A), (B), Y (C)...
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| creator | GOODING, OWEN, W REPKE, DAVID, B TEITELBAUM, PHILIP, J MARTINEZ, GREGORY, R WHITING, ROGER, L WALKER, KEITH, A., M |
| description | LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA DE **FORMULA**, DONDE N ES 0, 1 O 2; T ES O, 1, 2 O 3; R1 ES, INDEPENDIENTEMENTE, HALO, HIDROXI, O CSUB,1-4ALQUILOXI; Y R2 ESTA UNIDO EN POSICION AL, BE O GA, Y ES UN GRUPO SELECCIONADO ENTRE LAS FORMULAS (A), (B), Y (C), LOS CUALES SON INHIBIDORES DE DOPAMINA BE-HIDROXILASA, EN LOS CUALES LA PORCION BENZOCICLO-ALQUIL DEL COMPUESTO SE SELECCIONA ENTRE INDANIL, 1,2,3,4-TETRAHIDRONAFTENIL Y 6,7,8,9-TETRAHIDRO-5H-BENZOCICLO-HEPTENIL (EN EL CUAL EL BENZO SE SUSTITUYE OPCIONALMENTE CON DOS O TRES SUSTITUYENTES), Y LA PORCION AZOLTIONA DEL COMPUESTO SE SELECCIONA ENTRE 2-TIOXO-2,3DIHIDRO-1H-IMIDAZOL-3-IL, 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]-TRIAZOL4-IL Y 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]TRIAZOL-1-IL, (CADA UNO OPCIONALMENTE SUSTITUIDO POR , DESDE UNO HASTA TRES SUSTITUYENTES); Y LOS PRECURSORES DE MEDICAMENTOS, SALES FARMACEUTICAMENTE ACEPTABLES, ISOMEROS INDIVIDUALES, Y MEZCLAS DE ISOMEROS, ASI COMO LOS METODOS DE UTILIZACION Y PREPARACION DE DICHOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA.
The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ES2201104TT3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ES2201104TT3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ES2201104TT33</originalsourceid><addsrcrecordid>eNrjZNB0cQ3yDHN08Q9WcHFVcHL1i_J39nT28fdwjfD08fT1dHGM8vcJ8fT3c-RhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGuwUZGBoaGBiYhIcbGxKgBAFNKJQY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>DERIVADOS DE BENZOCICLOHEXILIMIDAZOLTIONA</title><source>esp@cenet</source><creator>GOODING, OWEN, W ; REPKE, DAVID, B ; TEITELBAUM, PHILIP, J ; MARTINEZ, GREGORY, R ; WHITING, ROGER, L ; WALKER, KEITH, A., M</creator><creatorcontrib>GOODING, OWEN, W ; REPKE, DAVID, B ; TEITELBAUM, PHILIP, J ; MARTINEZ, GREGORY, R ; WHITING, ROGER, L ; WALKER, KEITH, A., M</creatorcontrib><description>LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA DE **FORMULA**, DONDE N ES 0, 1 O 2; T ES O, 1, 2 O 3; R1 ES, INDEPENDIENTEMENTE, HALO, HIDROXI, O CSUB,1-4ALQUILOXI; Y R2 ESTA UNIDO EN POSICION AL, BE O GA, Y ES UN GRUPO SELECCIONADO ENTRE LAS FORMULAS (A), (B), Y (C), LOS CUALES SON INHIBIDORES DE DOPAMINA BE-HIDROXILASA, EN LOS CUALES LA PORCION BENZOCICLO-ALQUIL DEL COMPUESTO SE SELECCIONA ENTRE INDANIL, 1,2,3,4-TETRAHIDRONAFTENIL Y 6,7,8,9-TETRAHIDRO-5H-BENZOCICLO-HEPTENIL (EN EL CUAL EL BENZO SE SUSTITUYE OPCIONALMENTE CON DOS O TRES SUSTITUYENTES), Y LA PORCION AZOLTIONA DEL COMPUESTO SE SELECCIONA ENTRE 2-TIOXO-2,3DIHIDRO-1H-IMIDAZOL-3-IL, 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]-TRIAZOL4-IL Y 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]TRIAZOL-1-IL, (CADA UNO OPCIONALMENTE SUSTITUIDO POR , DESDE UNO HASTA TRES SUSTITUYENTES); Y LOS PRECURSORES DE MEDICAMENTOS, SALES FARMACEUTICAMENTE ACEPTABLES, ISOMEROS INDIVIDUALES, Y MEZCLAS DE ISOMEROS, ASI COMO LOS METODOS DE UTILIZACION Y PREPARACION DE DICHOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA.
The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.</description><edition>7</edition><language>spa</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040316&DB=EPODOC&CC=ES&NR=2201104T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040316&DB=EPODOC&CC=ES&NR=2201104T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GOODING, OWEN, W</creatorcontrib><creatorcontrib>REPKE, DAVID, B</creatorcontrib><creatorcontrib>TEITELBAUM, PHILIP, J</creatorcontrib><creatorcontrib>MARTINEZ, GREGORY, R</creatorcontrib><creatorcontrib>WHITING, ROGER, L</creatorcontrib><creatorcontrib>WALKER, KEITH, A., M</creatorcontrib><title>DERIVADOS DE BENZOCICLOHEXILIMIDAZOLTIONA</title><description>LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA DE **FORMULA**, DONDE N ES 0, 1 O 2; T ES O, 1, 2 O 3; R1 ES, INDEPENDIENTEMENTE, HALO, HIDROXI, O CSUB,1-4ALQUILOXI; Y R2 ESTA UNIDO EN POSICION AL, BE O GA, Y ES UN GRUPO SELECCIONADO ENTRE LAS FORMULAS (A), (B), Y (C), LOS CUALES SON INHIBIDORES DE DOPAMINA BE-HIDROXILASA, EN LOS CUALES LA PORCION BENZOCICLO-ALQUIL DEL COMPUESTO SE SELECCIONA ENTRE INDANIL, 1,2,3,4-TETRAHIDRONAFTENIL Y 6,7,8,9-TETRAHIDRO-5H-BENZOCICLO-HEPTENIL (EN EL CUAL EL BENZO SE SUSTITUYE OPCIONALMENTE CON DOS O TRES SUSTITUYENTES), Y LA PORCION AZOLTIONA DEL COMPUESTO SE SELECCIONA ENTRE 2-TIOXO-2,3DIHIDRO-1H-IMIDAZOL-3-IL, 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]-TRIAZOL4-IL Y 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]TRIAZOL-1-IL, (CADA UNO OPCIONALMENTE SUSTITUIDO POR , DESDE UNO HASTA TRES SUSTITUYENTES); Y LOS PRECURSORES DE MEDICAMENTOS, SALES FARMACEUTICAMENTE ACEPTABLES, ISOMEROS INDIVIDUALES, Y MEZCLAS DE ISOMEROS, ASI COMO LOS METODOS DE UTILIZACION Y PREPARACION DE DICHOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA.
The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB0cQ3yDHN08Q9WcHFVcHL1i_J39nT28fdwjfD08fT1dHGM8vcJ8fT3c-RhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfGuwUZGBoaGBiYhIcbGxKgBAFNKJQY</recordid><startdate>20040316</startdate><enddate>20040316</enddate><creator>GOODING, OWEN, W</creator><creator>REPKE, DAVID, B</creator><creator>TEITELBAUM, PHILIP, J</creator><creator>MARTINEZ, GREGORY, R</creator><creator>WHITING, ROGER, L</creator><creator>WALKER, KEITH, A., M</creator><scope>EVB</scope></search><sort><creationdate>20040316</creationdate><title>DERIVADOS DE BENZOCICLOHEXILIMIDAZOLTIONA</title><author>GOODING, OWEN, W ; REPKE, DAVID, B ; TEITELBAUM, PHILIP, J ; MARTINEZ, GREGORY, R ; WHITING, ROGER, L ; WALKER, KEITH, A., M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2201104TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2004</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GOODING, OWEN, W</creatorcontrib><creatorcontrib>REPKE, DAVID, B</creatorcontrib><creatorcontrib>TEITELBAUM, PHILIP, J</creatorcontrib><creatorcontrib>MARTINEZ, GREGORY, R</creatorcontrib><creatorcontrib>WHITING, ROGER, L</creatorcontrib><creatorcontrib>WALKER, KEITH, A., M</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GOODING, OWEN, W</au><au>REPKE, DAVID, B</au><au>TEITELBAUM, PHILIP, J</au><au>MARTINEZ, GREGORY, R</au><au>WHITING, ROGER, L</au><au>WALKER, KEITH, A., M</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DERIVADOS DE BENZOCICLOHEXILIMIDAZOLTIONA</title><date>2004-03-16</date><risdate>2004</risdate><abstract>LA PRESENTE INVENCION SE REFIERE A NUEVOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA DE **FORMULA**, DONDE N ES 0, 1 O 2; T ES O, 1, 2 O 3; R1 ES, INDEPENDIENTEMENTE, HALO, HIDROXI, O CSUB,1-4ALQUILOXI; Y R2 ESTA UNIDO EN POSICION AL, BE O GA, Y ES UN GRUPO SELECCIONADO ENTRE LAS FORMULAS (A), (B), Y (C), LOS CUALES SON INHIBIDORES DE DOPAMINA BE-HIDROXILASA, EN LOS CUALES LA PORCION BENZOCICLO-ALQUIL DEL COMPUESTO SE SELECCIONA ENTRE INDANIL, 1,2,3,4-TETRAHIDRONAFTENIL Y 6,7,8,9-TETRAHIDRO-5H-BENZOCICLO-HEPTENIL (EN EL CUAL EL BENZO SE SUSTITUYE OPCIONALMENTE CON DOS O TRES SUSTITUYENTES), Y LA PORCION AZOLTIONA DEL COMPUESTO SE SELECCIONA ENTRE 2-TIOXO-2,3DIHIDRO-1H-IMIDAZOL-3-IL, 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]-TRIAZOL4-IL Y 5-TIOXO-4,5-DIHIDRO-1H-[1,2,4]TRIAZOL-1-IL, (CADA UNO OPCIONALMENTE SUSTITUIDO POR , DESDE UNO HASTA TRES SUSTITUYENTES); Y LOS PRECURSORES DE MEDICAMENTOS, SALES FARMACEUTICAMENTE ACEPTABLES, ISOMEROS INDIVIDUALES, Y MEZCLAS DE ISOMEROS, ASI COMO LOS METODOS DE UTILIZACION Y PREPARACION DE DICHOS COMPUESTOS BENZOCICLO-ALQUILAZOLTIONA.
The present invention relates to novel benzocycloalkylazolethione compounds of formula (I) in which n is 0, 1 or 2; t is 0, 1, 2 or 3; R is independently halo, hydroxy or (C1-4)alkyloxy; and R is attached to the alpha , beta or gamma -position and is a group selected from formulae (a), (b) and (c) which are dopamine beta -hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-4-yl and 5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-1-yl (each optionally substituted with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVADOS DE BENZOCICLOHEXILIMIDAZOLTIONA |
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