DERIVADOS AZA-ANTRACICLINONA

COMPUESTOS DE FORMULA (1) EN DONDE X SUB,1} Y X SUB,2} SON C = O, C = NH O CH SUB,2}, X SUB,3} ES CH SUB,2}, CO, CHOH, DE FORMULA (III), DE FORMULA (IV) EN DONDE N=2 O 3, Y C = N(R SUB,9}) EN DONDE R SUB,9} ES HIDROXI O AMINO-ARILO, Y CADA UNO DE LOS R SUB,1}, R SUB,2}, R SUB,3}, R SUB,4}, R SUB,5}, R SUB,6}, R SUB,7} Y R SUB,8} SON HIDROGENO, HALOGENO O UN RESIDUO ORGANICO, UTILES EN EL TRATAMIENTO DE LA AMILOIDOSIS. TAMBIEN SE DESCRIBE UN PROCESO PARA SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. PCT No. PCT/EP96/03237 Sec. 371 Date Feb. 9, 1998 Sec. 102(e) Date Feb. 9, 1998 PCT Filed Jul. 23, 1996 PCT Pub. No. WO97/06165 PCT Pub. Date Feb. 20, 1997Compounds of formula I wherein X1 and X2 are C=O, C=NH or CH2, X3 is CH2, CO, CHOH, wherein n=2 or, 3 or C=N(R9) wherein R9 is hydroxy or amino-aryl, and each of R1, R2, R3, R4, R5, R6, R7 and R8 are hydrogen, halogen or an organic residue, are useful in the treatment of amyloidosis. A process for their preparation and pharmaceutical compositions containing them are also described.