PRECURSOR DE IMPLANTE BIODEGRADABLE

LA INVENCION SE REFIERE A UN PRECURSOR DE INJERTO BIODEGRADABLE, QUE TIENE UNA ESTRUCTURA DE DOS PARTES HECHAS DE UNA BOLSA EXTERIOR Y UN CONTENIDO LIQUIDO. EL PRECURSOR DE INJERTO ESTA FORMADO POR UN POLIMERO TERMOPLASTICO COAGULABLE EN AGUA Y BIODEGRADABLE, Y UN DISOLVENTE ORGANICO MISCIBLE EN AGU...

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Hauptverfasser:	NORTON, RICHARD L, LOWE, BRYAN K, SWANBOM, DERYL D, COX, CHARLES P, DUNN, RICHARD L, POLSON, ALAN M
Format:	Patent
Sprache:	spa
Schlagworte:	AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DENTISTRY DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROSTHESES SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDEDFOR SHAPING OR JOINING OF PLASTICS TRANSPORTING TREATMENT OR PROTECTION OF EYES OR EARS WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Zusammenfassung:	LA INVENCION SE REFIERE A UN PRECURSOR DE INJERTO BIODEGRADABLE, QUE TIENE UNA ESTRUCTURA DE DOS PARTES HECHAS DE UNA BOLSA EXTERIOR Y UN CONTENIDO LIQUIDO. EL PRECURSOR DE INJERTO ESTA FORMADO POR UN POLIMERO TERMOPLASTICO COAGULABLE EN AGUA Y BIODEGRADABLE, Y UN DISOLVENTE ORGANICO MISCIBLE EN AGUA. CUANDO SE ADMINISTRA A UN LUGAR DEL INJERTO EN UN ANIMAL, EL PRECURSOR DEL INJERTO SE SOLIDIFICARA IN SITU A UNA MATRIZ MICROPOROSA, SOLIDA, MEDIANTE LA DISIPACION DEL DISOLVENTE ORGANICO PARA RODEAR FLUIDOS DE TEJIDOS Y COAGULACION DEL POLIMERO. LA INVENCION TAMBIEN INCLUYE METODOS PARA HACER EL PRECURSOR DE INJERTOS, UN APARATO PARA FORMAR EL PRECURSOR, Y UN EQUIPO QUE CONTIENE EL APARATO. TAMBIEN SE PROPORCIONAN METODOS DE USO DEL PRECURSOR DE INJERTOS PARA TRATAR UN DEFECTO DEL TEJIDO EN UN ANIMAL, POR EJEMPLO, PARA REFORZAR EL DESARROLLO CELULAR Y REGENERACION DEL TEJIDO, CURACION DE HERIDAS Y ORGANOS, REGENERACION DE NERVIOS, REGENERACION DE TEJIDOS DUROS Y BLANDOS, Y SIMILARES, PARA ENTREGA DE SUSTANCIAS BIOLOGICAMENTE ACTIVAS A TEJIDOS U ORGANOS, Y OTRAS TERAPIAS. The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.