BIFENILSULFONILCIANAMIDAS, PROCEDIMIENTO PARA SU PREPARACION Y SU UTILIZACION COMO MEDICAMENTO

LOS COMPUESTOS DE LA FORMULA I, EN LOS CUALES LOS SIMBOLOS TIENEN LOS SIGNIFICADOS INDICADOS EN LAS REIVINDICACIONES, POSEEN PROPIEDADES ESPECIALES ANTIARRITMICAS Y TIENEN UN COMPONENTE CARDIOPROTECTOR. SE PUEDEN, DE MANERA PREVENTIVA, INHIBIR O IMPEDIR LOS PROCESOS PATOFISIOLOGICOS CON LA APARICION DE DAÑOS INDUCIDOS ISQUEMICAMENTE, EN PARTICULAR CUANDO SE PRODUCEN ARRITMIAS CARDIACAS INDUCIDAS ISQUEMICAMENTE. ADEMAS TIENEN UN FUERTE EFECTO INHIBIDOR EN LA PROLIFERACION DE CELULAS. Biphenylsulphonylcyanamides of formula (I) and their salt are new: R1 = H, 1-8C alkyl, 1-naphthyl, 2-naphthyl, 3-7C cycloalkyl, (3-7C)cycloalkyl(1-2C)alkyl, or phenyl or phenyl(1-2C)alkyl optionally ring-substituted by 1-3 of 1-8C alkyl, halogen, CF3, SOnR11, OR17, NR8R9, CN, NO2 or COR22; R11 = 1-4C alkyl or NR20R21; R20, R21 = H or 1-4C alkyl; R17 = H or 1-4C alkyl; R8, R9 = H or 1-4C alkyl; R22 = H, 1-8C alkyl or OR30; R30 = H or 1-8C alkyl; n = 0-2; or CR1R3 = 3-7C cycloalkylidene or fluorenylidene; R2-R5 = H, F, CF3, OR10, 1-8C alkyl, 3-7C cycloalkyl, or phenyl or phenyl(1-2C)alkyl optionally ring-substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR18R19; R18, R19 = H or 1-4C alkyl; R10 = H, 1-8C alkyl, or phenyl or 1-9C heteroaryl optionally substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR12R13; R12, R13 = H or 1-4C alkyl; or R2+R4 = a second bond; R6, R7 = H, halogen, CF3, CN, NO2, SOpR16, COR23 or OR24; R23 = H, 1-8C alkyl or OR25; R25 = H or 1-8C alkyl; R24 = H, 1-8C alkyl, or phenyl optionally substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR28R29; R28 and R29 = H or 1-4C alkyl; R16 = 1-8C alkyl, or phenyl optionally substituted by 1-3 of halogen, CF3, Me, OMe, OH or NR26R27; R26, R27 = H or 1-4C alkyl; p = 0-2.