PROMOTERS OF THE GENES GLUTAMATE DESHYDROGENASE, beta -N-ACETYLHEXOSAMINIDASE AND DOLLAR b(g)-ACTINE, AND THEIR USE IN SYSTEMS OF EXPRESSION, SECRETION AND ANTI-SENS IN FILAMENTARY FUNGI

The invention relates to promoters of the genes glutamate desydrogenase, beta -acetylhexosaminidase and gamma -actine and their use in systems of expression, secretion and anti-sens of filamentary funghi. The invention also relates to the use of the promoters of the genes which code: (I) glutamate d...

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Hauptverfasser:	SALTO MALDONADO FRANCISCO, DIEZ GARCIA BRUNO, BARREDO FUENTE JOSE LUIS, RODRIGUEZ SAIZ MARTA, MORENO VALLE MIGUEL ANGEL, COLLADOS DE LA VIEJA ALFONSO J
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	The invention relates to promoters of the genes glutamate desydrogenase, beta -acetylhexosaminidase and gamma -actine and their use in systems of expression, secretion and anti-sens of filamentary funghi. The invention also relates to the use of the promoters of the genes which code: (I) glutamate desydrogenase NADP depending (EC.1.4.1.4) of Penicillium chrysogenum, (II) gamma -N-actylhexosaminidase (EC.3.2.1.52) of Penicillium chrysogenum and (III) gamma -actine of Penicillium chrysogenum and Acrimonium chrysogenum, which can be used for the construction of potent vectors of expression and secretion useful both for P. chrysogenum and for A. chrysogenum and related species. Said promoters can also be used for blocking the genic expression through anti-sens construction. Under the control of the above mentioned promoters, it is possible to conduct the expression of other genes in filamentary fungi, thereby increasing the production of antibiotics and/or proteins inherent to the same. Promotores de los genes glutamato deshidrogenasa, {b -N-acetilhexosaminidasa y {y -actina y su utilización en sistemas de expresión, secreción y antisentido de hongos filamentosos. Se describe la utilización de los promotores de los genes que codifican: (I) glutamato deshidrogenasa NADP dependiente (EC.1.4.1.4) de Penicillium chrysogenum, (II) {b -N-acetilhexosaminidasa (EC.3.2.1.52) de Penicillium chrysogenum y (III) {y -actina de Penicillium chrysogenum y Acremonium chrysogenum, los cuales pueden ser utilizados para la construcción de potentes vectores de expresión y secreción útiles tanto para P. chrysogenum como para A. chrysogenum y especies relacionadas. Asimismo, estos promotores pueden utilizarse para el bloqueo de la expresión génica mediante construcciones antisentido. Bajo el control de los promotores anteriormente citados se puede dirigir la expresión de otros genes en hongos filamentosos, incrementándose la producción de antibióticos y/o proteínas inherentes a losimismos.