Process for obtaining (+/-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine

Process for obtaining (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine which comprises reducing ethyl (+-)-trans-4-(4-fluorophenyl)-2-piperidinone-5- carboxylate with lithium aluminium hydride or boranes to yield (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethylpiperidine, which is N-m...

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Hauptverfasser:	CARULLA OLIVER JOSE MARIA, DALMASES BARJOAN PERE, MARQUILLAS OLONDRIZ FRANCISCO, BOSCH ROVIRA ANNA, HERBERA ESPINAL M. DE LOS REYES
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	CARULLA OLIVER JOSE MARIA DALMASES BARJOAN PERE MARQUILLAS OLONDRIZ FRANCISCO BOSCH ROVIRA ANNA HERBERA ESPINAL M. DE LOS REYES
description	Process for obtaining (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine which comprises reducing ethyl (+-)-trans-4-(4-fluorophenyl)-2-piperidinone-5- carboxylate with lithium aluminium hydride or boranes to yield (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethylpiperidine, which is N-methylated with formaldehyde to yield the compound of formula I. PROCEDIMIENTO PARA LA OBTENCION DE (+)-TRANS-4-(4-FLUORO-FENIL)-3-HIDROXIMETIL-1-METILPIPERIDINA QUE CONSISTE EN LA REDUCCION DE (+)-TRANS-4-(4-FLUOROFENIL)-2-PIPERIDINONA-5-CARBOXILATO DE ETILO, CON HIDRURO DE LITIO Y ALUMINIO O BORANOS PARA DAR LA (+)-TRANS-4-(4-FLUOROFENIL)-3-HIDROXIMETILPIPERIDINA, EL CUAL SE N-METILA CON FORMALDEHIDO PARA DAR EL COMPUESTO DE FORMULA I.
format	Patent
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PROCEDIMIENTO PARA LA OBTENCION DE (+)-TRANS-4-(4-FLUORO-FENIL)-3-HIDROXIMETIL-1-METILPIPERIDINA QUE CONSISTE EN LA REDUCCION DE (+)-TRANS-4-(4-FLUOROFENIL)-2-PIPERIDINONA-5-CARBOXILATO DE ETILO, CON HIDRURO DE LITIO Y ALUMINIO O BORANOS PARA DAR LA (+)-TRANS-4-(4-FLUOROFENIL)-3-HIDROXIMETILPIPERIDINA, EL CUAL SE N-METILA CON FORMALDEHIDO PARA DAR EL COMPUESTO DE FORMULA I.</description><edition>6</edition><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19981201&DB=EPODOC&CC=ES&NR=2121685A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19981201&DB=EPODOC&CC=ES&NR=2121685A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CARULLA OLIVER JOSE MARIA</creatorcontrib><creatorcontrib>DALMASES BARJOAN PERE</creatorcontrib><creatorcontrib>MARQUILLAS OLONDRIZ FRANCISCO</creatorcontrib><creatorcontrib>BOSCH ROVIRA ANNA</creatorcontrib><creatorcontrib>HERBERA ESPINAL M. 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DE LOS REYES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CARULLA OLIVER JOSE MARIA</au><au>DALMASES BARJOAN PERE</au><au>MARQUILLAS OLONDRIZ FRANCISCO</au><au>BOSCH ROVIRA ANNA</au><au>HERBERA ESPINAL M. DE LOS REYES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Process for obtaining (+/-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine</title><date>1998-12-01</date><risdate>1998</risdate><abstract>Process for obtaining (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine which comprises reducing ethyl (+-)-trans-4-(4-fluorophenyl)-2-piperidinone-5- carboxylate with lithium aluminium hydride or boranes to yield (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethylpiperidine, which is N-methylated with formaldehyde to yield the compound of formula I. 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language	eng ; spa
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	Process for obtaining (+/-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine
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