Process for obtaining (+/-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine

Process for obtaining (+/-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine

Process for obtaining (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine which comprises reducing ethyl (+-)-trans-4-(4-fluorophenyl)-2-piperidinone-5- carboxylate with lithium aluminium hydride or boranes to yield (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethylpiperidine, which is N-m...

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Bibliographische Detailangaben
Hauptverfasser: CARULLA OLIVER JOSE MARIA, DALMASES BARJOAN PERE, MARQUILLAS OLONDRIZ FRANCISCO, BOSCH ROVIRA ANNA, HERBERA ESPINAL M. DE LOS REYES
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Process for obtaining (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethyl-1-methylpiperidine which comprises reducing ethyl (+-)-trans-4-(4-fluorophenyl)-2-piperidinone-5- carboxylate with lithium aluminium hydride or boranes to yield (+-)-trans-4-(4-fluorophenyl)-3- hydroxymethylpiperidine, which is N-methylated with formaldehyde to yield the compound of formula I. PROCEDIMIENTO PARA LA OBTENCION DE (+)-TRANS-4-(4-FLUORO-FENIL)-3-HIDROXIMETIL-1-METILPIPERIDINA QUE CONSISTE EN LA REDUCCION DE (+)-TRANS-4-(4-FLUOROFENIL)-2-PIPERIDINONA-5-CARBOXILATO DE ETILO, CON HIDRURO DE LITIO Y ALUMINIO O BORANOS PARA DAR LA (+)-TRANS-4-(4-FLUOROFENIL)-3-HIDROXIMETILPIPERIDINA, EL CUAL SE N-METILA CON FORMALDEHIDO PARA DAR EL COMPUESTO DE FORMULA I.