PROCESS FOR THE PRODUCTION OF CLAVULANIC ACID AND/OR SALTS THEREOF

A batch fermentation is carried out continuously or semicontinuously using strains of Streptomyces clavuligerus ATCC 27064 or mutants thereof. The fermentation process is carried out with a strict control of the soluble phosphate in the medium, both at the beginning and throughout the process. As a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	RODRIGUEZ OTERO CARMELITA, MORENO VALLE MIGUEL ANGEL, LOPEZ NIETO MANUEL JESUS
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A batch fermentation is carried out continuously or semicontinuously using strains of Streptomyces clavuligerus ATCC 27064 or mutants thereof. The fermentation process is carried out with a strict control of the soluble phosphate in the medium, both at the beginning and throughout the process. As a carbon source, lipids, preferably triglycerides can be used. Substantial increases in the production of the antibiotic are obtained. LA INVENCION CONSISTE EN UN NUEVO PROCEDIMIENTO PARA LA OBTENCION DE ACIDO CLAVULANICO MEDIANTE EL CUAL, CON UN CONTROL RIGUROSO DEL NIVEL DE FOSFATO SOLUBLE DURANTE LA FERMENTACION, SE PUEDE INCREMENTAR NOTABLEMENTE SU PRODUCCION. EL PROCESO SE LLEVA A CABO A PARTIR DE CEPAS SELECCIONADAS, O MUTANTES DE LAS MISMAS, OBTENIDAS A PARTIR DE STREPTOMYCES CLAVULIGERUS ATCC 27064. LA ADICION, TANTO DEL ION FOSFATO COMO DEL RESTO DE NUTRIENTES, PUEDE HACERSE AL INICIO DE LA FERMENTACION O DISTRIBUIDO A LO LARGO DE LA MISMA.