PIPERIDINAS 1,4-SUBSTITUIDAS COMO INHIBIDORES DE LA ACETILCOLINESTERASA Y SU UTILIZACION EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER

UN COMPUESTO DE AMINA CICLICA DEFINIDO POR LA FORMULA (I) EN LA QUE LOS SUSTITUYENTES TIENEN EL SIGNIFICADO DE LA INVENCION. ELCOMPUESTO ES UTIL PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS Y PARA MEDICAMENTOS CONTRA LA DEMENCIA SENIL. Cyclic amine cpds. of formula (I) and their salts are new. - J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. - 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.