NEW N,N,N',N'-TETRASUBSTITUTED-1,2-ETHANEDIAMINE DERIVATIVE COMPOUNDS

The invention relates to new N,N,N',N'-tetra-substituted-1,2-ethanediamine compounds of general formula (I), wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p-F-C6H4-CH) group and R is a benzyl group optionally substituted in p- with an halogen, or R is a 2...

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Hauptverfasser: FOGUET AMBROS RAFAEL, ORTIZ HERNANDEZ JOSE A, SACRISTAN MUNOZ AURELIO, CASTELLO BARENYS JOSEP M, GUBERT RIBERA SANTIAGO
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The invention relates to new N,N,N',N'-tetra-substituted-1,2-ethanediamine compounds of general formula (I), wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p-F-C6H4-CH) group and R is a benzyl group optionally substituted in p- with an halogen, or R is a 2-pyrimidinyl group with the proviso that simultaneously X may not be p-fluorophenyl-methylen (p-F-C6H4-CH) and R may not be an unsubstituted benzyl group, as well as their pharmaceutically acceptable addition salts. The compounds are potentially useful in the treatment of sigma receptor-related nervous system diseases. NUEVOS COMPUESTOS DERIVADOS DE LA 1,2-ETANODIAMINA-N,N,N",N''-TETRASUSTITUIDA. CONSISTE EN LOS NUEVOS COMPUESTOS DERIVADOS DE LA 1,2-ETANODIAMINA-N,N,N",N''-TETRASUSTITUIDA, DE FORMULA GENERAL (I): *FIG* DONDE "X" ES UN GRUPO CARBONILO (CO), HIDROXIMETILEN (CHOH) O P-FLUOROFENIL-METILEN (P-F-C6H4-CH) Y "R" ES UN RESTO BENCILO OPCIONALMENTE SUSTITUIDO EN P- POR UN HALOGENO O BIEN ES UN RESTO 2PIRIMIDINIL, A CONDICION DE QUE SIMULTANEAMENTE "X" NO SEA P-FLUOROFENIL-METILEN (P-F-C6H4-CH) Y "R" NO SEA UN RESTO BENCILO NO SUSTITUIDO, ASI COMO SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS SON DE USO POTENCIAL PARA TRATAR ENFERMEDADES DEL SISTEMA NERVIOSO SOMETIDAS A CONTROL DE LOS RECEPTORES SI.