Process for obtaining polymers with antiviral activity

The present invention consists in a process for obtaining polymers with antiviral activity which is characterised in that in water or in mixtures of water with water-miscible solvents, ruder specific conditions of temperature, time, and pH, molecules carrying carbonyl groups and hydroxyl groups in a...

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Hauptverfasser: CARRASCO LLAMAS LUIS, GUERRERO BENITO CARMEN, ALMENA ARMENDARIZ MARIA JESUS, GUERRERO GOMEZ-PAMO ANTONIO F, LEAL OJEDA JUAN ANTONIO, PIVEL RANIERI JUAN PABLO
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present invention consists in a process for obtaining polymers with antiviral activity which is characterised in that in water or in mixtures of water with water-miscible solvents, ruder specific conditions of temperature, time, and pH, molecules carrying carbonyl groups and hydroxyl groups in alpha position relative to the carbonyl, such as monosaccharides, react with molecules carrying amino and sulfonated groups, such as aliphatic amino-sulfonates in that after the reaction ends, the polymeric material is purified by conventional processes, such that its molecular weight is within the range from 1,500 to 100,000 in that this polymeric material has antiviral activity and either lacks or presents very low toxicity and anticoagulant activity, and is thus suitable for production of pharmaceutical preparations suitable for use in topical or systemic antiviral therapy in humans or in animals. It is applicable in the pharmaceutical industry. PROCEDIMIENTO PARA LA OBTENCION DE POLIMEROS DOTADOS DE ACTIVIDAD ANTIVIRAL, QUE SE CARACTERIZA PORQUE SE HACEN REACCIONAR EN AGUA O EN MEZCLAS DE AGUA CON SOLVENTES MISCIBLES CON AGUA, EN CONDICIONES DETERMINADAS DE TEMPERATURA, TIEMPO Y PH, MOLECULAS PORTADORAS DE GRUPOS CARBONILO E HIDROXILO EN POSICION RESPECTO AL CARBONILO, COMO POR EJEMPLO MONOSACARIDOS CON MOLECULAS PORTADORAS DE GRUPOS DE GRUPOS AMINO Y SULFONATO, COMO POR EJEMPLO AMINOSULFONATOS ALIFATICOS; PORQUE UNA VEZ CONCLUIDA LA REACCION SE PURIFICA EL MATERIAL POLIMERICO POR PROCEDIMIENTOS QUIMICOS TRADICIONALES, DE MODO QUE SU PESO MOLECULAR ESTE COMPRENDIDO EN EL RANGO 1.500-100.00. TIENE APLICACION EN LA INDUSTRIA FARMACEUTICA.