Dioxazocine derivatives compositions and methods containing them having antidepressive, spasmolytic, anticonvulsive, and antiarrhythmic properties

Dioxazocine derivatives, their preparation and composition containing them, said derivatives being represented by the formula I < IMAGE > (I) wherein R1 represents hydrogen or alkyl having from 1 to 4 carbon atoms, R2 represents alkyl having from 1 to 4 carbon atoms, and n is equal to 0 or 1, and pharmaceutically acceptable acid addition salts thereof formed with an inorganic or organic acid. Two different reactions are described for making these compounds. They can be formulated into pharmaceutical compositions in the usual manner and exhibit central nervous system affecting activities. PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE DIOXAZOCINA, REPRESENTADOS POR LA FORMULA (I) DONDE R1 REPRESENTA HIDROGENO O ALQUILO DE 1 A 4 ATOMOS DE CARBONO; R2 REPRESENTA ALQUILO DE 1 A 4 ATOMOS DE CARBONO, Y N ES IGUAL A 0 O 1, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES FORMADAS CON UN ACIDO INORGANICO U ORGANICO. SE DESCRIBEN DOS REACCIONES DIFERENTES PARA HACER ESTOS COMPUESTOS. PUEDEN FORMULARSE EN COMPOSICIONES FARMACEUTICAS DE LA MANERA HABITUAL Y EXHIBEN ACTIVIDADES SOBRE EL SISTEMA NERVIOSO CENTRAL.