Controlled release implants for administration of recombinant growth hormones

The present invention provides improved controlled release implants for subcutaneous administration to an animal of a growth promoting amount of a recombinant protein having growth hormone activity, characterised in that said protein is present in a form having a salt content of less than 5% by weig...

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Bibliographische Detailangaben
Hauptverfasser:	JANSKI ALVIN M, YANG REN-DER
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention provides improved controlled release implants for subcutaneous administration to an animal of a growth promoting amount of a recombinant protein having growth hormone activity, characterised in that said protein is present in a form having a salt content of less than 5% by weight based on the weight of said protein. PROCEDIMIENTO DE OBTENCION DE UN INJERTO DE LIBERACION CONTROLADA PARA LA ADMINISTRACION A UN ANIMAL DE HORMONA DE CRECIMIENTO, ESPECIALMENTE PROCEDIMIENTO PARA PURIFICAR Y CONCENTRAR HORMONA DE CRECIMIENTO BIOLOGICAMENTE ACTIVA PARA PRODUCIR HORMONA DE CRECIMIENTO EN UNA FORMA ADECUADA PARA SU INCORPORACION EN UN DISPOSITIVO O SISTEMA DE LIBERACION CONTROLADA. UNA SOLUCION TAMPONADA DE HORMONA DE CRECIMIENTO RECOMBINANTE PURIFICADA ES DIALIZADA CONTRA UNA SOLUCION TAMPONADA HASTA QUE EL NIVEL DE SAL SE REDUCE A MENOS DE 5%, TRAS LO CUAL SE SOMETE A LIOFILIZACION.