Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them
The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; spa |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | FOGUET AMBROS RAFAEL ORTIZ HERNANDEZ JOSE CASTELLO BARENYS JOSEP M DE ANDRES BASAURI LUIS CAYUELA GIMENEZ SALVADOR SAMPEDRO CAMARENA FEDERICO |
| description | The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon atoms, as well as to a process for preparing these compounds and to pharmaceutical compositions containing these compounds. These compounds are useful for treating tumor diseases.
CONSISTE EN LA REACCION DE LOS COMPUESTOS DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), OBTENIENDOSE ASI LOS NUEVOS COMPLEJOS DE PLATINO (II) DERIVADOS DEL 2,3-DIMERCAPTO-2-BUTENE-DINITRILATO (2-)-S,SK DE FORMULA GENERAL (I), DONDE R ES UN GRUPO DIALQUILSULFURO O TRIALQUILFOSFINA, DE MANERA QUE EL NUMERO DE CARBONOS DE CADA RADICAL ALQUILO ES DOS COMO MAXIMO, PUDIENDO CONTENER LOS RADICALES ALQUILO UN GRUPO HIDROXILO O NO. DE APLICACION FARMACOLOGICA POR SU EFECTO ANTITUMORAL. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_ES2000614A6</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ES2000614A6</sourcerecordid><originalsourceid>FETCH-epo_espacenet_ES2000614A63</originalsourceid><addsrcrecordid>eNqNjU0KwjAQhbtxIeodZqnQQK3SvZSKrnUvY53agSQTkil4Cs9sQA_g6v3w8d68eLfigqUXJZABgkVlPzlYn88bqMudebBnjWzF1OY-KXky31pHlkxTCQghSk8pwSAxewoY2T9BR3KA_gFhxOiwp0m5Rwt9fpTEyuJTDl4xf_z4ZTEb0CZa_XRRwLG7tidDQW6UQl7xpLfuUldV1Wz3h2b3B_IB1adMhA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them</title><source>esp@cenet</source><creator>FOGUET AMBROS RAFAEL ; ORTIZ HERNANDEZ JOSE ; CASTELLO BARENYS JOSEP M ; DE ANDRES BASAURI LUIS ; CAYUELA GIMENEZ SALVADOR ; SAMPEDRO CAMARENA FEDERICO</creator><creatorcontrib>FOGUET AMBROS RAFAEL ; ORTIZ HERNANDEZ JOSE ; CASTELLO BARENYS JOSEP M ; DE ANDRES BASAURI LUIS ; CAYUELA GIMENEZ SALVADOR ; SAMPEDRO CAMARENA FEDERICO</creatorcontrib><description>The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon atoms, as well as to a process for preparing these compounds and to pharmaceutical compositions containing these compounds. These compounds are useful for treating tumor diseases.
CONSISTE EN LA REACCION DE LOS COMPUESTOS DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), OBTENIENDOSE ASI LOS NUEVOS COMPLEJOS DE PLATINO (II) DERIVADOS DEL 2,3-DIMERCAPTO-2-BUTENE-DINITRILATO (2-)-S,SK DE FORMULA GENERAL (I), DONDE R ES UN GRUPO DIALQUILSULFURO O TRIALQUILFOSFINA, DE MANERA QUE EL NUMERO DE CARBONOS DE CADA RADICAL ALQUILO ES DOS COMO MAXIMO, PUDIENDO CONTENER LOS RADICALES ALQUILO UN GRUPO HIDROXILO O NO. DE APLICACION FARMACOLOGICA POR SU EFECTO ANTITUMORAL.</description><edition>4</edition><language>eng ; spa</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880301&DB=EPODOC&CC=ES&NR=2000614A6$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880301&DB=EPODOC&CC=ES&NR=2000614A6$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FOGUET AMBROS RAFAEL</creatorcontrib><creatorcontrib>ORTIZ HERNANDEZ JOSE</creatorcontrib><creatorcontrib>CASTELLO BARENYS JOSEP M</creatorcontrib><creatorcontrib>DE ANDRES BASAURI LUIS</creatorcontrib><creatorcontrib>CAYUELA GIMENEZ SALVADOR</creatorcontrib><creatorcontrib>SAMPEDRO CAMARENA FEDERICO</creatorcontrib><title>Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them</title><description>The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon atoms, as well as to a process for preparing these compounds and to pharmaceutical compositions containing these compounds. These compounds are useful for treating tumor diseases.
CONSISTE EN LA REACCION DE LOS COMPUESTOS DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), OBTENIENDOSE ASI LOS NUEVOS COMPLEJOS DE PLATINO (II) DERIVADOS DEL 2,3-DIMERCAPTO-2-BUTENE-DINITRILATO (2-)-S,SK DE FORMULA GENERAL (I), DONDE R ES UN GRUPO DIALQUILSULFURO O TRIALQUILFOSFINA, DE MANERA QUE EL NUMERO DE CARBONOS DE CADA RADICAL ALQUILO ES DOS COMO MAXIMO, PUDIENDO CONTENER LOS RADICALES ALQUILO UN GRUPO HIDROXILO O NO. DE APLICACION FARMACOLOGICA POR SU EFECTO ANTITUMORAL.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjU0KwjAQhbtxIeodZqnQQK3SvZSKrnUvY53agSQTkil4Cs9sQA_g6v3w8d68eLfigqUXJZABgkVlPzlYn88bqMudebBnjWzF1OY-KXky31pHlkxTCQghSk8pwSAxewoY2T9BR3KA_gFhxOiwp0m5Rwt9fpTEyuJTDl4xf_z4ZTEb0CZa_XRRwLG7tidDQW6UQl7xpLfuUldV1Wz3h2b3B_IB1adMhA</recordid><startdate>19880301</startdate><enddate>19880301</enddate><creator>FOGUET AMBROS RAFAEL</creator><creator>ORTIZ HERNANDEZ JOSE</creator><creator>CASTELLO BARENYS JOSEP M</creator><creator>DE ANDRES BASAURI LUIS</creator><creator>CAYUELA GIMENEZ SALVADOR</creator><creator>SAMPEDRO CAMARENA FEDERICO</creator><scope>EVB</scope></search><sort><creationdate>19880301</creationdate><title>Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them</title><author>FOGUET AMBROS RAFAEL ; ORTIZ HERNANDEZ JOSE ; CASTELLO BARENYS JOSEP M ; DE ANDRES BASAURI LUIS ; CAYUELA GIMENEZ SALVADOR ; SAMPEDRO CAMARENA FEDERICO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ES2000614A63</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>1988</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>FOGUET AMBROS RAFAEL</creatorcontrib><creatorcontrib>ORTIZ HERNANDEZ JOSE</creatorcontrib><creatorcontrib>CASTELLO BARENYS JOSEP M</creatorcontrib><creatorcontrib>DE ANDRES BASAURI LUIS</creatorcontrib><creatorcontrib>CAYUELA GIMENEZ SALVADOR</creatorcontrib><creatorcontrib>SAMPEDRO CAMARENA FEDERICO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FOGUET AMBROS RAFAEL</au><au>ORTIZ HERNANDEZ JOSE</au><au>CASTELLO BARENYS JOSEP M</au><au>DE ANDRES BASAURI LUIS</au><au>CAYUELA GIMENEZ SALVADOR</au><au>SAMPEDRO CAMARENA FEDERICO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them</title><date>1988-03-01</date><risdate>1988</risdate><abstract>The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon atoms, as well as to a process for preparing these compounds and to pharmaceutical compositions containing these compounds. These compounds are useful for treating tumor diseases.
CONSISTE EN LA REACCION DE LOS COMPUESTOS DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), OBTENIENDOSE ASI LOS NUEVOS COMPLEJOS DE PLATINO (II) DERIVADOS DEL 2,3-DIMERCAPTO-2-BUTENE-DINITRILATO (2-)-S,SK DE FORMULA GENERAL (I), DONDE R ES UN GRUPO DIALQUILSULFURO O TRIALQUILFOSFINA, DE MANERA QUE EL NUMERO DE CARBONOS DE CADA RADICAL ALQUILO ES DOS COMO MAXIMO, PUDIENDO CONTENER LOS RADICALES ALQUILO UN GRUPO HIDROXILO O NO. DE APLICACION FARMACOLOGICA POR SU EFECTO ANTITUMORAL.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; spa |
| recordid | cdi_epo_espacenet_ES2000614A6 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T07%3A17%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=FOGUET%20AMBROS%20RAFAEL&rft.date=1988-03-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EES2000614A6%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |