Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them

Complexes of platinum (II) 2,3-dinitrilo-2-butene-2,3-dithiolate, a process for preparing them and pharmaceutical compositions containing them

The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon...

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Hauptverfasser: FOGUET AMBROS RAFAEL, ORTIZ HERNANDEZ JOSE, CASTELLO BARENYS JOSEP M, DE ANDRES BASAURI LUIS, CAYUELA GIMENEZ SALVADOR, SAMPEDRO CAMARENA FEDERICO
Format: Patent
Sprache:eng ; spa
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The invention relates to platinum(II) complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-S,S' derivatives having the general formula (I): < CHEM > wherein R is a dialkylsulphide or trialkylphosphine group and each alkyl group may contain one or more hydroxyl groups and has 1 to 2 carbon atoms, as well as to a process for preparing these compounds and to pharmaceutical compositions containing these compounds. These compounds are useful for treating tumor diseases. CONSISTE EN LA REACCION DE LOS COMPUESTOS DE FORMULA GENERAL (II) CON UN COMPUESTO DE FORMULA GENERAL (III), OBTENIENDOSE ASI LOS NUEVOS COMPLEJOS DE PLATINO (II) DERIVADOS DEL 2,3-DIMERCAPTO-2-BUTENE-DINITRILATO (2-)-S,SK DE FORMULA GENERAL (I), DONDE R ES UN GRUPO DIALQUILSULFURO O TRIALQUILFOSFINA, DE MANERA QUE EL NUMERO DE CARBONOS DE CADA RADICAL ALQUILO ES DOS COMO MAXIMO, PUDIENDO CONTENER LOS RADICALES ALQUILO UN GRUPO HIDROXILO O NO. DE APLICACION FARMACOLOGICA POR SU EFECTO ANTITUMORAL.