PEPTIDE LINKERS COMPRISING TWO OR MORE PAYLOADS

The present invention relates to a peptide linker comprising (a) an amino acid residue comprising a primary amine; and (b) two or more payloads; wherein each of the two or more payloads can be independently attached to: (i) an N-terminal end of the peptide linker, (ii) a C-terminal end of the peptid...

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Bibliographische Detailangaben
Hauptverfasser:	FAY, Rachael, SPYCHER, Philipp, GRABULOVSKI, Dragan, BERTRAND, Romain, ATTINGER-TOLLER, Isabella
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a peptide linker comprising (a) an amino acid residue comprising a primary amine; and (b) two or more payloads; wherein each of the two or more payloads can be independently attached to: (i) an N-terminal end of the peptide linker, (ii) a C-terminal end of the peptide linker, or (iii) a side chain of an amino acid residue comprised in the peptide linker. Further, the present invention relates to antibody-payload conjugates comprising the peptide linker of the invention, methods for generating said antibody-payload conjugates and uses thereof.