CRYSTALLINE FORMS OF AN MCL-1 INHIBITOR

Disclosed herein are crystalline forms of (4S,7aR,9aR, 10R, 11E, 14S, 15R)-6'-chloro-10-methoxy-14, 15- dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3',4',7a,8,9,9a,10, 13, 14, 15-decahydro- 2'H, 3H, 5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4] oxazepino[3,...

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Bibliographische Detailangaben
Hauptverfasser:	XIAO, Lingyun, KELLY, Ron, C, CHAVES, Mary, PARENT, Stephan, STEC, Markian, ACHMATOWICZ, Michal, TENG, Jing, HUCKLE, James, E, LUU, Van, REID, Darren, L, FARRELL, Robert, P, WU, Tian
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed herein are crystalline forms of (4S,7aR,9aR, 10R, 11E, 14S, 15R)-6'-chloro-10-methoxy-14, 15- dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3',4',7a,8,9,9a,10, 13, 14, 15-decahydro- 2'H, 3H, 5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4] oxazepino[3, 4-f] [1,2,7]thiadiazacyclohexadecine-4,1'- naphthalene]-16, 16, 18(7H, 17H)-trione (AMG 397): (AMG 397), hydrates, and solvates thereof. Also disclosed are methods of making the crystalline forms, and methods of treating diseases and disorders with the crystalline forms.