TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS

TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH MENIN INHIBITORS AND P-GLYCOPROTEIN INHIBITORS

The present disclosure provides methods for treating hematological malignancies using menin inhibitors in combination with P-gp inhibitors and/or BCRP inhibitors. Compositions for use in these methods are also provided.

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Bibliographische Detailangaben
Hauptverfasser: ZHU, Xuefeng, BURROWS, Francis, LEONI, Mollie, MALIK, Shivani, GREENE, Douglas, MCCLOSKEY, Asako
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides methods for treating hematological malignancies using menin inhibitors in combination with P-gp inhibitors and/or BCRP inhibitors. Compositions for use in these methods are also provided.