METHOD OF PREPARATION OF 1-(N-(QUINOLIN-2-YL)- (PHENYLAMINO)-1-DEOXY-BETA-D-GLUCOPYRANURONIC ACID DERIVATIVES

METHOD OF PREPARATION OF 1-(N-(QUINOLIN-2-YL)- (PHENYLAMINO)-1-DEOXY-BETA-D-GLUCOPYRANURONIC ACID DERIVATIVES

The present invention relates to a process of purification of a crude compound of formula (I)wherein it comprises an isolation step of said crude compound of formula (I) including: (i) a solubilization step of said crude compound of formula (I) with methanol followed by a precipitation step with wat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DENIS, Jérôme, ROSE, Sébastien, MAGUEUR, Guillaume
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The present invention relates to a process of purification of a crude compound of formula (I)wherein it comprises an isolation step of said crude compound of formula (I) including: (i) a solubilization step of said crude compound of formula (I) with methanol followed by a precipitation step with water, and (ii) a drying step under a temperature inferior or equal to 30°C.Herein is further provided a m manufacturing process for preparing a compound of formula (I).