8-AZA QUINAZOLINES AS BRAIN-PENETRANT SOS1-INHIBITORS

The present invention relates to small molecules capable of inhibiting SOS1 (Son of Sevenless) and their salts. Specifically, the present invention relates to heterocyclic compounds of general formula (I) or salts thereof wherein A, X, R1, R2, R3 have one of the meanings as indicated in the specific...

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Bibliographische Detailangaben
Hauptverfasser:	MUELLER, Stephan Georg, WUNBERG, Tobias, GIOVANNINI, Riccardo, HEINE, Niklas, HOHN, Christoph, RAMHARTER, Juergen
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to small molecules capable of inhibiting SOS1 (Son of Sevenless) and their salts. Specifically, the present invention relates to heterocyclic compounds of general formula (I) or salts thereof wherein A, X, R1, R2, R3 have one of the meanings as indicated in the specification. Furthermore, the invention relates to pharmaceutical compositions and combinations comprising these compounds, as well as their use in methods for the treatment of diseases associated with or modulated by SOS1.