A PREPARATION OF QUINAZOLINEDIONES AND USE THEREOF

A PREPARATION OF QUINAZOLINEDIONES AND USE THEREOF

The present invention described herein relates to a compound having Structure I for treating diseases and disorders for which inhibition or modulation of the Ubiquitin Ligase COP1 enzyme produces a physiologically beneficial response, in particular for the treatment of Non-Alcoholic Fatty Liver Dise...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HOQUE, Israful, TALUKDAR, Arindam, GHOSH DASTIDAR, Uddipta, SARKAR, Dipayan, GOON, Sunny, SEN, Abhishek, CHOWDHURY, Saheli, PATRA, Binita, CHAKRABARTI, Partha
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention described herein relates to a compound having Structure I for treating diseases and disorders for which inhibition or modulation of the Ubiquitin Ligase COP1 enzyme produces a physiologically beneficial response, in particular for the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD). These compounds having Structure I are capable of increasing the level of adipose triglyceride lipase (ATGL). Also provided is the process of preparing compounds having Structure I.