IONIZABLE DISULFIDE LIPIDS AND LIPID NANOPARTICLES DERIVED THEREFROM

Ionizable lipids with a disulfide moiety and lipid nanoparticles comprising said lipids are disclosed. In select preferred embodiments, the ionizable lipids have a structure of formulae 11-15. The lipid nanoparticles formed from the ionizable lipids can be used as delivery vehicles for medicinal sma...

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Bibliographische Detailangaben
Hauptverfasser:	GOPALAKRISHNA PANICKER, Rajesh Krishnan, KARPOV, Yury, OLSEN, Kirstin
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Ionizable lipids with a disulfide moiety and lipid nanoparticles comprising said lipids are disclosed. In select preferred embodiments, the ionizable lipids have a structure of formulae 11-15. The lipid nanoparticles formed from the ionizable lipids can be used as delivery vehicles for medicinal small molecules, antibodies, nucleotides, and polypeptides. Such nanoparticles can be used as vaccines or the treatment of cancer.