VARIANTS OF THERMOSTABLE DNA PRIMASES AND USES THEREOF

The present invention relates to a functionally active mutated primase domain from an archaeal DNA primase belonging to the primase-polymerase family, comprising at least one amino acid substitution, wherein said mutated primase domain retains at least 50% of the template-independent terminal nucleo...

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Bibliographische Detailangaben
Hauptverfasser: RANDRIANJATOVO-GBALOU, Irina, RAHIER, Renaud, SAID, Ahmed
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to a functionally active mutated primase domain from an archaeal DNA primase belonging to the primase-polymerase family, comprising at least one amino acid substitution, wherein said mutated primase domain retains at least 50% of the template-independent terminal nucleotidyl transferase activity of the corresponding wild-type primase domain.