DUAL MHC-TARGETING T CELL ENGAGER

DUAL MHC-TARGETING T CELL ENGAGER

Described herein are antigen binding proteins comprising a Fab domain which specifically binds to a cell surface protein of an immune cell, a first pMHC binding domain, and a second pMHC binding domain. Methods of treating cancer or a viral infection with the same are also described.

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Bibliographische Detailangaben
Hauptverfasser: SOBIERAJ, Anna Maria, BORRAS, Leonardo, MERTEN, Hannes, JUNGMICHEL, Stephanie, SCHEIFELE, Fabian Bert, RICHLE, Philipp Robert
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Described herein are antigen binding proteins comprising a Fab domain which specifically binds to a cell surface protein of an immune cell, a first pMHC binding domain, and a second pMHC binding domain. Methods of treating cancer or a viral infection with the same are also described.