BENZOTHIOPHENE DERIVATIVES AS RXFP1 AGONISTS

The disclosure relates to compounds of Formula (I), which are RXFP1 agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e...

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Bibliographische Detailangaben
Hauptverfasser:	BHOGADI, Vikram, PINTO, Donald, J. P, SMITH II, Leon M, PASUNOORI, Laxman, ORWAT, Michael J, KUMAR, Sreekantha Ratna, SRINIVAS, Pitani Veera Venkata, HEGDE, Subramanya, BARRE, Durga Buchi Raju, DURAISAMY, Srinivasan Kunchithaptham
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure relates to compounds of Formula (I), which are RXFP1 agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension). Variables X1, X2, R1, R2, and R4 are as defined in the disclosure.