POLYNUCLEOTIDE COMPOSITIONS AND USES THEREOF

POLYNUCLEOTIDE COMPOSITIONS AND USES THEREOF

The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA 5molecules, RNA-LNPs an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SIMON, Raphael, DIAZ, Fernando Martin, DONALD, Robert George Konrad, CHE, Ye, LI, Jin, CHORRO, Laurent Olivier, SILMON DE MONERRI, Natalie Clare
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to RNA molecules encoding an E. coli fimbrial H antigen (FimH). The present disclosure further relates to compositions comprising the RNA molecules formulated in a lipid nanoparticle (RNA-LNP). The present disclosure further relates to the use of the RNA 5molecules, RNA-LNPs and compositions for the prevention of E.coli infection, including urinary tract infection.