METHOD AND APPARATUS FOR STERILE AND NONINVASIVE MEASUREMENTS OF SUBSTANCES IN BIOREACTORS AND OTHER STERILE ENVIRONMENTS

METHOD AND APPARATUS FOR STERILE AND NONINVASIVE MEASUREMENTS OF SUBSTANCES IN BIOREACTORS AND OTHER STERILE ENVIRONMENTS

The present invention provides for systems and method for noninvasive measurement and monitoring of cell culture parameters including dissolved oxygen (DO), dissolved carbon dioxide (DCO2), and pH wherein there is no direct contact with the cell culture environment which is achieved by conducting th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RAO, Govind, KUMAR, Vikash, TOLOSA, Michael, RAHMATNEJAD, Vida, GE, Xudong
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention provides for systems and method for noninvasive measurement and monitoring of cell culture parameters including dissolved oxygen (DO), dissolved carbon dioxide (DCO2), and pH wherein there is no direct contact with the cell culture environment which is achieved by conducting the measurements and monitoring on the outside of the bioreactor through semi-permeable membranes incorporated into the system to enhance the process and eliminate the risk of contamination associated with invasive sensors.