KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES

The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.

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Bibliographische Detailangaben
Hauptverfasser:	Broeker, Joachim, McLennan, Ross, Weinstabl, Harald, Gollner, Andreas, Zhong, Siying, Waterson, Alex, Hodges, Tim, Smethurst, Christian Alan Paul, Zollman, David, Diers, Emelyne, Cui, Jianwen, Schmiedel, Martin, Little, Andrew, Mantoulidis, Andreas, Abbott, Jason, Kofink, Christiane, Ciulli, Aleissio, Sarkar, Dhruba, Fesik, Stephen W, Trainor, Nicole, Goodwin-Tindall, Jake, Farnaby, William, Popow, Johannes
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.