A BIOREACTOR COMPRISING A BAFFLE

A bioreactor 4 for cell culture comprises a container 12 having a base 15 and a side wall 16 defining an internal volume. The bioreactor also has a lid 13 that closes the internal volume of the container. The base is moveable towards and away from the lid. The bioreactor also includes a baffle member 22 mounted to the lid and positioned in the internal volume of the container such that the baffle member is arranged to mix contents of the bioreactor as the base is moved relative to the lid. The baffle may slide or rotate in the lid and may comprise holes (30, Fig. 6), openings (31, Fig. 7, 34, Fig. 8), or ribs (32, Fig. 9). A fluid path (43, Fig. 19) may convey fluid through the baffle and may comprise a filter (44, Fig. 19). A system comprising the bioreactor and an agitator (36, Fig. 18) is also provided. The agitator may change the angle of the base relative to the baffle member. A method of cell culture using the bioreactor system is also provided. The system is intended to mix the fluid contents of the bioreactor and agitate a cell suspension during cell culture.