FRAGMENT CONSENSUS METHODS FOR ULTRASENSITIVE DETECTION OF ABERRANT METHYLATION

Provided herein are methods related to detecting DNA methylation (e.g., level of methylation at CpG dinucleotide cluster(s)), as well as methods of treatment, uses, systems, and computer readable storage media related thereto. These methods allow for detection of aberrant DNA methylation patterns wi...

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Bibliographische Detailangaben
Hauptverfasser:	PETERMAN, Neil, ROBERTSON, Alexander De Jong, LAMBERT, Nicole Jacinda
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are methods related to detecting DNA methylation (e.g., level of methylation at CpG dinucleotide cluster(s)), as well as methods of treatment, uses, systems, and computer readable storage media related thereto. These methods allow for detection of aberrant DNA methylation patterns with low background and increased signal-to-background ratio, which can be useful, inter alia, in the early detection or monitoring of cancer.