MUTANTS OF A LIGAND-DEPENDENT COREPRESSOR (LCOR) AND USES THEREOF

MUTANTS OF A LIGAND-DEPENDENT COREPRESSOR (LCOR) AND USES THEREOF

The present invention provides a novel and improved cancer therapy based on an isolated or synthesized polynucleotide sequence coding for a mutant of a Ligand-dependent corepressor (LCOR), or a fragment thereof, capable of inducing expression of the antigen processing/presentation machinery (APM) ge...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PALOMEQUE ALARCON, José Ángel, ALBANELL MESTRES, Joan, PÉREZ NÚÑEZ, Iván, SERRA MIR, Gabriel, CELIÀ TERRASSA, Antoni
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention provides a novel and improved cancer therapy based on an isolated or synthesized polynucleotide sequence coding for a mutant of a Ligand-dependent corepressor (LCOR), or a fragment thereof, capable of inducing expression of the antigen processing/presentation machinery (APM) genes, wherein the mutant or fragment of a Ligand-dependent corepressor (LCOR) is characterized by comprising a functional HTH domain, and wherein said mutant or fragment of a Ligand-dependent corepressor (LCOR) is further characterized by comprising an absent or inactivated Nuclear Receptor Binding Domain.