INCREASED LIPID PRODUCTION THROUGH METABOLIC ACTIVATION WITH IONIZING RADIATION

A method and system is provided for increasing lipids, biomass, and metabolite yields of a microalgae culture of cells and other organisms with conserved metabolic pathways compared to an untreated culture or organism when maintained under normal conditions. The method includes irradiating with elec...

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Bibliographische Detailangaben
Hauptverfasser:	JEVTOVIC, Mima, VOJVODIC, Snezana, LIZZUL, Alessandro, Marco, STANIC, Marina, PITTMAN, Jon, K, DIMITRIJEVIC, Milena, LUKOVIC, Jelena Danilovic, SPASOJEVIC, Ivan, ZECHMANN, Bernd
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A method and system is provided for increasing lipids, biomass, and metabolite yields of a microalgae culture of cells and other organisms with conserved metabolic pathways compared to an untreated culture or organism when maintained under normal conditions. The method includes irradiating with electromagnetic ionizing radiation to induce rapid and reproducible hormetic metabolic activation in the organism cells. In an embodiment, the irradiation can be applied in a exponential or stationary phase of microalgae growth. The hormetic effect involves up-regulation of expression of lipid metabolism genes encoding enzymes that are involved in the biosynthesis of lipids with accumulation of energy reserves in the form of lipids and/or accumulation of other metabolites. The method can be implemented in a system that can interface with existing microalgae cultivation platforms, standard microalgae cultivation conditions, alongside standard microalgae culture types, and similarly with organisms with conserved metabolic pathways in their growth substrates.