OLIGONUCLEOTIDES FOR MODULATING APOLIPOPROTEIN E4 EXPRESSION

The present invention relates to antisense oligonucleotides that are capable of modulating expression of Apolipoprotein E4 (ApoE4) in a target cell. The oligonucleotides can hybridize to APOE ε4 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compo...

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Bibliographische Detailangaben
Hauptverfasser:	FOO, Lynette, KIELPINSKI, Lukasz, NYMARK, Helle, MOELHART HOEG, Anja, PEDERSEN, Lykke
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to antisense oligonucleotides that are capable of modulating expression of Apolipoprotein E4 (ApoE4) in a target cell. The oligonucleotides can hybridize to APOE ε4 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of, for example, Alzheimer's disease (AD), fronto-temporal dementia (FTD), Pick's disease (PiD), progressive supranuclear palsy (PSP), movement disorders such as Parkinson's disease (PD), dementia with Lewy Bodies, dementia in Down's Syndrome, and Niemann-Pick Type C1 Disease.