SIGNALING DOMAINS FOR CHIMERIC ANTIGEN RECEPTORS

SIGNALING DOMAINS FOR CHIMERIC ANTIGEN RECEPTORS

Disclosed are chimeric antigen receptors (CARs), comprising an antigen binding domain, a transmembrane domain; a costimulatory domain; and a signaling domain comprising one of a CD3ε signaling domain, a CD3γ signaling domain, a CD3δ signaling domain, or a DAP12 signaling domain. Disclosed is a nucle...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GUEVARA, Claudia I, WYMAN, Sarah K, FENG, Jun, AYVAR, Ricardo, MURAKAMI, Jodi, NOWYHED, Heba N
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are chimeric antigen receptors (CARs), comprising an antigen binding domain, a transmembrane domain; a costimulatory domain; and a signaling domain comprising one of a CD3ε signaling domain, a CD3γ signaling domain, a CD3δ signaling domain, or a DAP12 signaling domain. Disclosed is a nucleic acid encoding a CAR and recombinant vector comprising such nucleic acids. Disclosed is a host cell comprising such nucleic acids and recombinant vectors, and a pharmaceutical composition comprising such host cells. Disclosed is method of treating disease in a patient in need of thereof, or inducing an immune response in a subject or immunizing a subject against a cancer.