SYSTEMS, DEVICES, AND METHODS FOR FLUORESCENCE IMAGING WITH IMAGING PARAMETER MODULATION

Systems, devices, and methods provide for the operation of a portable, hand-held device comprising an illumination device including at least one excitation light source and a driver configured to drive the at least one excitation light source to sequentially produce a plurality of output intensities; an imaging device configured to capture a plurality of fluorescence images of a target surface respectively corresponding to the plurality of output intensities; a memory; and a processor configured to: co-register the plurality of fluorescence images, divide an image area into a plurality of sections, for each of the plurality of sections, select an image portion from one of the plurality of fluorescence images, and combine the selected image portions to generate a composite image.