BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM

BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM

The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R5 and X are as described herein.Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and met...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RUNTZ-SCHMITT, Valerie, HUMM, Roland, HANLON, Steven Paul, HERNANDEZ, Maria-Clemencia, KOBLET, Andreas, OLIVARES MORALES, Andrés Miguel, GOBBI, Luca, CECERE, Giuseppe
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R5 and X are as described herein.Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds for the treatment or prevention of acute neurological disorders, chronic neurological disorders and/or cognitive disorders.