LONG-ACTING BREXPIPRAZOLE PREPARATION FOR INJECTION AND PREPARATION METHOD THEREFOR

A long-acting brexpiprazole preparation for injection and a preparation method therefor. The preparation method therefor comprises: (a) dissolving brexpiprazole in an organic solvent to form a brexpiprazole solution; (b1) pumping the brexpiprazole solution into a sheared or violently stirred precipi...

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Hauptverfasser: WEI, Wei, SU, Zhengxing, LIANG, Xiangyong, YI, Cong, KE, Duo, WANG, Jingyi, LIU, Sichuan, LI, Ming, LI, Dan, ZHAO, Dong
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A long-acting brexpiprazole preparation for injection and a preparation method therefor. The preparation method therefor comprises: (a) dissolving brexpiprazole in an organic solvent to form a brexpiprazole solution; (b1) pumping the brexpiprazole solution into a sheared or violently stirred precipitation solvent, so as to precipitate brexpiprazole, or (b2) pumping the precipitation solvent into the sheared or violently stirred brexpiprazole solution, so as to precipitate brexpiprazole; (c) filtering and optionally using water to wash an obtained solid; and (d1) drying the obtained solid, and respectively packaging the dried solid and an auxiliary material solution to obtain the long-acting brexpiprazole preparation for injection, or (d2) dispersing the obtained solid into the auxiliary material solution to obtain the long-acting brexpiprazole preparation for injection.