FORMULATIONS OF IMMUNE CHECK POINT INHIBITORS OR LIKE

The present invention discloses a stable buffer free formulation of anti-PD1/anti-PD-L1 antibody, comprising an anti-PD1 or an anti-PD-L1 antibody, water, mannitol and surfactant, and stabilized at a pH of about 5.0-about 6.0. The disclosed antibody formulation is a liquid formulation and can be lyo...

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Bibliographische Detailangaben
Hauptverfasser: R, Shalaka, LABALA, Suman, TALABATTULA, Giridhar Purushottam, K GOUD, Saisharan, JAYARAMAN, Murali, SIGIREDDI, Indra Kumar, NANKAR, Sunil Ashok, BASKARAN, Lalithkumar
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention discloses a stable buffer free formulation of anti-PD1/anti-PD-L1 antibody, comprising an anti-PD1 or an anti-PD-L1 antibody, water, mannitol and surfactant, and stabilized at a pH of about 5.0-about 6.0. The disclosed antibody formulation is a liquid formulation and can be lyophilized. Further, the said formulation is also suitable for different mode of administration such as subcutaneous/intravenous, for therapeutic use.