PREPARATORY PROCESS

The disclosure provides a process of preparing an iron complexed conjugate between a desferrioxamine chelating ligand and a protein, the process being undertaken at a substantially neutral pH. A process of exposing an iron complexed conjugate to a free chelating ligand selected from desferrioxamine,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WHEATCROFT, Michael Paul, STERRITT, Oliver William
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The disclosure provides a process of preparing an iron complexed conjugate between a desferrioxamine chelating ligand and a protein, the process being undertaken at a substantially neutral pH. A process of exposing an iron complexed conjugate to a free chelating ligand selected from desferrioxamine, a desferrioxamine analogue, and HBED, at a substantially neutral pH, in order to remove chelated iron from the iron complexed conjugate is also disclosed.